Amyloid - , Soluble APP - and - Kinetics during BACE Inhibition
نویسندگان
چکیده
X Justyna A. Dobrowolska,1 Maria S. Michener,5 Guoxin Wu,3 Bruce W. Patterson,2 Robert Chott,2 Vitaliy Ovod,1 Yuriy Pyatkivskyy,1 Kristin R. Wildsmith,1 Tom Kasten,1 Parker Mathers,5 Mandy Dancho,5 Christina Lennox,5 Brad E. Smith,5 David Gilberto,5 Debra McLoughlin,8 Daniel J. Holder,7 Andrew W. Stamford,6 Kevin E. Yarasheski,2 Matthew E. Kennedy,4 Mary J. Savage,3 and Randall J. Bateman1 1Departments of Neurology and 2Medicine, Washington University School of Medicine, St. Louis, Missouri 63110 and 3Molecular Biomarkers, 4Neuroscience, 5Safety and Laboratory Animal Resources, 6Medicinal Chemistry, 7Early Development Statistics, and 8Preclinical Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486 and Kenilworth, New Jersey 07033
منابع مشابه
CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.
BACE, a β-secretase, is an attractive potential disease-modifying therapeutic strategy for Alzheimer's disease (AD) as it results directly in the decrease of amyloid precursor protein (APP) processing through the β-secretase pathway and a lowering of CNS amyloid-β (Aβ) levels. The interaction of the β-secretase and α-secretase pathway-mediated processing of APP in the rhesus monkey (nonhuman pr...
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تاریخ انتشار 2014